Endocrine Abstracts

Increased survival rates especially among young cancer patients have resulted in more and more fertility centers worldwide have acknowledged that fertility preservation is becoming an important quality of life issue to the growing population of cancer survivors treated during their fertile years. If the ovaries become depleted of follicles the woman will become sterile, loose menstrual cycles and many women experience profound effects on the physical and psychological status. ...

The luteinising hormone/chorionic gonadotropin receptor (LHCGR) plays an essential role in ovarian follicular function, mediating the action of LH on theca cell steroidogenesis and, in the preovulatory follicle, on granulosa cell (GC) steroid production and the ovulatory cascade. Following ovulation, LH (and CG) are responsible for maintenance and function of the corpus luteum. Arrested antral follicle development in PCOS is characterised by premature responsiveness of GCs to ...